I came across a great quote from Ev's keynote at SXSW. It's meant to be his big lesson to other entrepreneurs, but really it works for anyone.
Create something you want to exist in the world. Another is focus. Many people are trying to do a lot of things when they should be doing one thing. You may be wrong with whatever you’re trying out, but you’ll try other things.
A lot of the great companies are now coming from outside Silicon Valley. You don’t have to be there.